https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Ultra-Short Duration Hypothermia Prevents Intracranial Pressure Elevation Following Ischaemic Stroke in Rats https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43990 Wed 29 Mar 2023 14:36:31 AEDT ]]> Intracranial pressure elevation 24 h after ischemic stroke in aged rats is prevented by early, short hypothermia treatment https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29687 p = 0.03). Infarct and edema volumes were not significantly different between groups. These data demonstrate ICP may also increase 24 h post-stroke in aged rats, and that short-duration hypothermia treatment has a profound and sustained preventative effect. These findings may have important implications for the use of hypothermia in clinical trials of aged stroke patients.]]> Wed 19 Jan 2022 15:19:48 AEDT ]]> The inhibitory effects of Dracocephalum moldavica L. (DML) on rat cerebral ischemia reperfusion injury https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34032 Dracocephalum moldavica L. (DML), a Chinese herbal medicine is known to exert protective effects on myocardial ischemia reperfusion injury in rats by inhibiting oxidation damage and inflammatory reactions. However, the effectiveness of DML in cerebral ischemia reperfusion injury (CIRI) as a protective substance and the underlying mechanisms remain to be determined. The aim of this study was thus to examine the influence of DML on CIRI using a rat model induced by 2-h transient middle cerebral artery occlusion (MCAO) produced by intraluminal suture blockade followed by 22 h reperfusion. The parameters determined include neurological behavior, histochemical assessment of cerebral infarct volume, and determination of various metabolic biomarkers. Data showed that DML markedly improved neurobehavioral scores and reduced cerebral edema and infarction. In addition, DML significantly reduced malondialdehyde (MDA) content and elevated activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), in addition, marked decrease in levels of interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-a (TNF-a). Data suggest that the protective effects of DML on CIRI may be related to processes involving antioxidation and anti-inflammation.]]> Mon 04 Feb 2019 11:46:05 AEDT ]]> Ischemic penumbra as a trigger for intracranial pressure rise: a potential cause for collateral failure and infarct progression? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22101 Fri 16 Aug 2024 16:04:01 AEST ]]>